Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28866159 | 0.88 | PIM1 (0.53) | PIM1SMN1; SMN2NPC1RAB9AP4HTM | |
| SCHEMBL6287453 | 0.85 | HDAC1 (0.68) | PIM1HDAC3HDAC1GRM4HDAC4 | |
| SCHEMBL28183890 | 0.83 | PIM1 (0.47) | PIM1KMT2AHDAC3HDAC1GRM4 | |
| SCHEMBL28183741 | 0.82 | PIM1 (0.47) | PIM1SMN1; SMN2RAB9AGRM4GRM1 | |
| SCHEMBL13626622 | 0.82 | PIM1 (0.59) | PIM1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL20751634 | 0.82 | NPC1 (0.42) | PIM1SMN1; SMN2NPC1RAB9AP4HTM | |
| SCHEMBL30763136 | 0.81 | HDAC3 (0.71) | SMN1; SMN2NPC1RAB9AP4HTMMEN1 | |
| SCHEMBL5285570 | 0.81 | HDAC3 (0.71) | SMN1; SMN2NPC1RAB9AP4HTMMEN1 | |
| Ammonia Solution, Strong SCHEMBL27976383 | 0.81 | PIM1 (0.57) | PIM1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL19476138 | 0.79 | ALDH1A1 (0.63) | PIM1MEN1KMT2AGRM4GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104640858-B | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | 霍夫曼-拉罗奇有限公司 | 2018-11-06 | — | — | CN | claimed |
| CN-103987707-B | The base heterocyclic radical benzamide compound of pyrazoles 4 and application method | 霍夫曼-拉罗奇有限公司 | 2017-11-07 | — | — | CN | claimed |
| WO-2024082724-A1 | PIM KINASE INHIBITOR IN COMBINATION WITH KRAS INHIBITOR | NINGBO NEWBAY TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2024-04-25 | — | — | WO | disclosed |
| WO-2023202563-A1 | AKT INHIBITOR IN COMBINATION WITH PIM KINASE INHIBITOR | NEWBAY TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2023-10-26 | — | — | WO | disclosed |