Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.55 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | OGT | O15294 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA5A | P35218 | 3/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29946114 | 1.00 | STIM1 (0.55) | STIM1ORAI1FLT3GSK3BPTGS2 | |
| SCHEMBL28330114 | 0.83 | FLT3 (0.73) | FLT3GSK3BPTGS2PTGS1OGT | |
| SCHEMBL12420378 | 0.80 | FLT3 (0.69) | FLT3GSK3BPTGS2PTGS1OGT | |
| SCHEMBL28956663 | 0.80 | FLT3 (0.56) | STIM1ORAI1FLT3GSK3BPTGS2 | |
| SCHEMBL26628282 | 0.80 | BCHE (0.61) | STIM1ORAI1FLT3GSK3BPTGS2 | |
| SCHEMBL26628312 | 0.79 | PTGS2 (0.67) | FLT3GSK3BPTGS2PTGS1OGT | |
| SCHEMBL27166062 | 0.78 | NPC1 (0.56) | — | |
| SCHEMBL28337478 | 0.77 | FLT3 (0.65) | FLT3GSK3BPTGS2PTGS1OGT | |
| SCHEMBL28864459 | 0.77 | BCHE (0.57) | FLT3GSK3BPTGS2PTGS1OGT | |
| SCHEMBL28266900 | 0.76 | FLT3 (0.65) | FLT3GSK3BPTGS2PTGS1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4106871-B1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIV DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO (IT) | 2024-03-13 | — | — | EP | claimed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | claimed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | claimed |
| EP-4106871-B1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIV DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO (IT) | 2024-03-13 | — | — | EP | disclosed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | disclosed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | ORAI1, SARAF, STIM1 | STIM1 3/4885ORAI1 1/4885FLT3 4336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.