Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | CCR8 | P51685 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1988502 | 0.82 | POLB (0.50) | NPC1POLBKMT2AATMTDP1 | |
| SCHEMBL2646337 | 0.79 | NPC1 (0.68) | NPC1CCR8POLBKMT2AATM | |
| SCHEMBL14919311 | 0.76 | NPC1 (1.00) | NPC1CCR8KMT2AALDH1A1KDM4E | |
| SCHEMBL20021983 | 0.76 | KMT2A (0.71) | NPC1CCR8POLBKMT2AATM | |
| SCHEMBL13788913 | 0.74 | KMT2A (0.63) | NPC1CCR8POLBKMT2AATM | |
| SCHEMBL29688705 | 0.72 | L3MBTL1 (0.49) | NPC1POLBKMT2AATMTDP1 | |
| SCHEMBL8709633 | 0.71 | KMT2A (0.58) | NPC1POLBKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1338751 | 0.70 | CCR8 (1.00) | NPC1CCR8POLBKMT2AALDH1A1 | |
| SCHEMBL3247291 | 0.70 | CNR1 (0.56) | NPC1POLBKMT2AGAATSHR | |
| SCHEMBL3408339 | 0.70 | NPC1 (0.52) | NPC1CCR8POLBKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| WO-2000039088-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-06 | — | — | WO | disclosed |