Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CCR8 | P51685 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919311 | 0.81 | NPC1 (1.00) | NPC1ALDH1A1SMN1; SMN2CCR8KMT2A | |
| SCHEMBL15116254 | 0.81 | L3MBTL1 (0.61) | NPC1ALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL1911955 | 0.81 | ALDH1A1 (0.63) | NPC1ALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL2662832 | 0.79 | NPC1 (0.61) | NPC1ALDH1A1SMN1; SMN2CCR8POLB | |
| Hydrochloric Acid SCHEMBL28721405 | 0.78 | ALDH1A1 (0.60) | NPC1ALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL20021983 | 0.78 | KMT2A (0.71) | NPC1ALDH1A1SMN1; SMN2L3MBTL1CCR8 | |
| SCHEMBL2964786 | 0.76 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2POLBKMT2AMAPK1 | |
| SCHEMBL13788913 | 0.76 | KMT2A (0.63) | NPC1ALDH1A1SMN1; SMN2L3MBTL1CCR8 | |
| SCHEMBL22433209 | 0.75 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2L3MBTL1KMT2AMAPK1 | |
| SCHEMBL4265032 | 0.74 | CNR1 (0.62) | ALDH1A1SMN1; SMN2KMT2AATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-1140823-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039088-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-06 | — | — | WO | disclosed |