Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26628823 | 0.81 | NPSR1 (0.47) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL29734702 | 0.81 | NPSR1 (0.47) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL12316332 | 0.79 | HTT (0.53) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL24735855 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL29940033 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL24735678 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL28779898 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10HPGDPLK4 | |
| SCHEMBL28779894 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10HPGDPLK4 | |
| SCHEMBL23901206 | 0.76 | OPRK1 (0.46) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL28999518 | 0.76 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067613-A1 | NOVEL QUINAZOLINE DERIVATIVES AS SOS1 INHIBITORS AND USE THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2024-02-29 | — | — | US | disclosed |
| US-20240067613-A1 | NOVEL QUINAZOLINE DERIVATIVES AS SOS1 INHIBITORS AND USE THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2024-02-29 | — | — | US | disclosed |
| US-20240067613-A1 | NOVEL QUINAZOLINE DERIVATIVES AS SOS1 INHIBITORS AND USE THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2024-02-29 | — | — | US | disclosed |
| EP-4269395-A1 | NOVEL QUINAZOLINE DERIVATIVE COMPOUND AS SOS1 INHIBITOR, AND USE THEREOF | Hanmi Pharmaceutical Co., Ltd. (KR) | 2023-11-01 | — | — | EP | disclosed |
| EP-4269395-A1 | NOVEL QUINAZOLINE DERIVATIVE COMPOUND AS SOS1 INHIBITOR, AND USE THEREOF | Hanmi Pharmaceutical Co., Ltd. (KR) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022139304-A1 | NOVEL QUINAZOLINE DERIVATIVE COMPOUND AS SOS1 INHIBITOR, AND USE THEREOF | 한미약품 주식회사 | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067613-A1 | NOVEL QUINAZOLINE DERIVATIVES AS SOS1 INHIBITORS AND USE THEREOF | SOS1, RASGRP1, RAC1 | KDM4E 4163/4885ALDH1A1 3440/4885HSD17B10 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.