Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2663383 | 0.87 | KDM4E (0.37) | NPC1RAB9ASMN1; SMN2MAPTTPH1 | |
| SCHEMBL2663358 | 0.85 | STAT3 (0.55) | MAPTNR1H4PDK1STAT3 | |
| SCHEMBL9072822 | 0.83 | TPH1 (0.42) | NPC1RAB9ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL2663199 | 0.80 | HDAC1 (0.37) | NPC1RAB9ASMN1; SMN2MAPTCNR2 | |
| SCHEMBL2663352 | 0.78 | STAT3 (0.54) | STAT3 | |
| SCHEMBL4090978 | 0.76 | GCGR (0.46) | NPC1RAB9ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL2663329 | 0.75 | GCGR (0.40) | RAB9ASMN1; SMN2MAPTNR1H4MEN1 | |
| SCHEMBL9072930 | 0.73 | STAT3 (0.48) | STAT3MEN1KMT2A | |
| SCHEMBL2663375 | 0.73 | STAT3 (0.48) | STAT3 | |
| SCHEMBL2663367 | 0.72 | STAT3 (0.47) | STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |