SCHEMBL2663189

SCHEMBL2663189

N=N/C(=N\N)NC(=O)c1ccc(CN(C(=O)Cc2ccc(OC(F)(F)F)cc2)c2ccc(C3CCCCC3)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GCGR P47871 10/20 0.57
STAT3 P40763 10/20 0.46
GIPR P48546 8/20 0.43
GLP1R P43220 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2663162 0.94 GCGR (0.58) GCGRSTAT3GIPRGLP1R
SCHEMBL2663354 0.92 GCGR (0.50) GCGRSTAT3GIPR
SCHEMBL2663565 0.87 GCGR (0.54) GCGRSTAT3GIPRGLP1R
SCHEMBL2663367 0.85 STAT3 (0.47) GCGRSTAT3GIPR
SCHEMBL2663309 0.84 STAT3 (0.46) GCGRSTAT3GIPR
SCHEMBL2663352 0.84 STAT3 (0.54) GCGRSTAT3GIPR
SCHEMBL2663183 0.81 GCGR (0.41) GCGRSTAT3GIPR
SCHEMBL2663321 0.80 STAT3 (0.49) GCGRSTAT3GIPR
SCHEMBL2652600 0.80 GCGR (0.62) GCGRSTAT3GIPR
SCHEMBL2652606 0.80 GCGR (0.62) GCGRSTAT3GIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000069810-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2000-11-23 WO disclosed