Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26633912 | 0.86 | NAMPT (0.44) | SMN1; SMN2ALDH1A1MAPK1KEAP1NFE2L2 | |
| SCHEMBL26633778 | 0.83 | MEN1 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL26633733 | 0.80 | NAMPT (0.41) | KEAP1NFE2L2 | |
| SCHEMBL26633874 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ACASRALDH1A1 | |
| SCHEMBL24011184 | 0.79 | NAMPT (0.57) | CASRKEAP1NFE2L2 | |
| SCHEMBL24011100 | 0.77 | CYP2C9 (0.49) | SMN1; SMN2NPC1CASRKEAP1NFE2L2 | |
| SCHEMBL13366908 | 0.71 | CASR (0.63) | SMN1; SMN2NPC1RAB9ACASRALDH1A1 | |
| SCHEMBL12466536 | 0.71 | MEN1 (0.62) | SMN1; SMN2NPC1TSHRHRH3MEN1 | |
| SCHEMBL24011409 | 0.70 | CASR (0.59) | SMN1; SMN2NPC1RAB9ACASRALDH1A1 | |
| SCHEMBL26764081 | 0.70 | CNR1 (0.60) | SMN1; SMN2NPC1RAB9ACASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | NAMPT, NNT, NAPRT | SMN1; SMN2 610/4885NPC1 128/4885RAB9A 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.