SCHEMBL266345

SCHEMBL266345

O=C(Nc1ccc(N2CCCCC2)cc1C(=O)NN=Cc1ccc(Cl)c(C(F)(F)F)c1)c1cccc(CSCC(O)CO)c1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 12/20 0.62
SLC34A1 Q06495 1/20 0.62
SLC34A3 Q8N130 1/20 0.62
SLC20A1 Q8WUM9 1/20 0.62
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
GAA P10253 1/20 0.36
CYP2D6 P10635 1/20 0.36
MAPT P10636 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
CYP2C19 P33261 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HDAC1 Q13547 1/20 0.35
RAF1 P04049 1/20 0.34
ADCYAP1R1 P41586 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL266344 1.00 SLC34A2 (0.62) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL274492 1.00 SLC34A2 (0.62) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL274017 0.91 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL267364 0.91 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL267363 0.91 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL274508 0.90 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL266437 0.90 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL266436 0.90 SLC34A2 (0.49) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL268744 0.90 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2
SCHEMBL274658 0.90 SLC34A2 (0.47) SLC34A2SLC34A1SLC34A3SLC20A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885SLC34A1 4/4885SLC34A3 12/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885SLC34A1 1/4885SLC34A3 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.