SCHEMBL2664358

SCHEMBL2664358

O=C(NNCc1ccc(OCc2ccc(OC(F)(F)F)cc2)c2ccccc12)c1ccc(O)c(Cl)c1

nearest known ligand 0.69

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GCGR P47871 16/20 0.69
ADCYAP1R1 P41586 3/20 0.44
TRPV1 Q8NER1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2663872 0.85 GCGR (0.67) GCGRADCYAP1R1
SCHEMBL2663996 0.81 GCGR (1.00) GCGRADCYAP1R1
SCHEMBL2664360 0.80 GCGR (0.74) GCGRADCYAP1R1
SCHEMBL9072197 0.77 GCGR (0.56) GCGR
SCHEMBL2663760 0.75 GCGR (0.79) GCGR
SCHEMBL2664696 0.74 GCGR (0.78) GCGR
SCHEMBL2664107 0.73 GCGR (0.85) GCGRADCYAP1R1
SCHEMBL2664393 0.73 GCGR (1.00) GCGR
SCHEMBL2663863 0.73 GCGR (1.00) GCGR
SCHEMBL2663823 0.73 GCGR (0.54) GCGRADCYAP1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999001423-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 1999-01-14 WO disclosed