Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.40 |
| ▸ | CDK4 | P11802 | 5/20 | 0.40 |
| ▸ | CCND1 | P24385 | 5/20 | 0.40 |
| ▸ | CDK9 | P50750 | 5/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.40 |
| ▸ | CDK11A | Q9UQ88 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26647638 | 0.92 | PDE5A (0.57) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL290592 | 0.88 | PDE5A (0.66) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL290241 | 0.88 | PDE5A (0.68) | PDE5AALDH1A1HPGDMAPTLMNA | |
| SCHEMBL27937598 | 0.86 | PDE5A (0.52) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL27950966 | 0.85 | PDE5A (0.69) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL27950945 | 0.84 | PDE5A (0.57) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL28581338 | 0.82 | PDE5A (0.74) | PDE5AALDH1A1HPGDMAPTLMNA | |
| SCHEMBL299899 | 0.81 | PDE5A (0.47) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL290899 | 0.80 | PDE5A (0.53) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL28020392 | 0.80 | AURKA (0.48) | PDE5AALDH1A1HPGDAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103547267-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | OMEROS CORP | 2014-01-29 | — | — | CN | disclosed |