Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29831861 | 0.91 | PDE5A (0.67) | XDHPDE5ANPSR1NPC1RAB9A | |
| SCHEMBL290337 | 0.91 | PDE5A (0.67) | XDHPDE5ANPSR1NPC1RAB9A | |
| SCHEMBL26647596 | 0.86 | PDE5A (0.58) | PDE5ANPSR1RAB9ALMNAMAPT | |
| SCHEMBL27950934 | 0.85 | PDE5A (0.53) | PDE5ANPC1RAB9ANR1H4MAPT | |
| SCHEMBL27950930 | 0.85 | PDE5A (0.61) | PDE5ANPSR1NPC1RAB9ALMNA | |
| SCHEMBL27937575 | 0.85 | PDE5A (0.60) | PDE5ANPSR1LMNAMAPTKDM4E | |
| SCHEMBL27950940 | 0.84 | PDE5A (0.54) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27950936 | 0.84 | PDE5A (0.59) | PDE5AALDH1A1CCNT1CDK4CCND1 | |
| SCHEMBL27937611 | 0.83 | PDE5A (0.71) | PDE5ANPSR1NPC1RAB9ALMNA | |
| SCHEMBL27950964 | 0.82 | PDE5A (0.62) | PDE5ANPC1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275752-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | Omeros Corporation (US) | 2023-11-15 | — | — | EP | disclosed |