Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291287 | 0.90 | PDE5A (0.70) | PDE5ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL27950940 | 0.88 | PDE5A (0.54) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27937575 | 0.87 | PDE5A (0.60) | PDE5AMEN1KMT2ACCNT1CDK4 | |
| SCHEMBL27950936 | 0.86 | PDE5A (0.59) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL26647667 | 0.85 | XDH (0.52) | PDE5ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL26647596 | 0.85 | PDE5A (0.58) | PDE5ARAB9ACCNT1CDK4CCND1 | |
| SCHEMBL27950964 | 0.84 | PDE5A (0.62) | PDE5ANPC1CCNT1CDK4CCND1 | |
| SCHEMBL27950930 | 0.84 | PDE5A (0.61) | PDE5ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL27937605 | 0.84 | PDE5A (0.59) | PDE5ANPC1CCNT1CDK4CCND1 | |
| SCHEMBL27950958 | 0.83 | PDE5A (0.56) | PDE5AMEN1KMT2ACCNT1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103547267-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | OMEROS CORP | 2014-01-29 | — | — | CN | disclosed |