Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EEF2K | O00418 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26648261 | 1.00 | KDM4E (0.46) | KDM4EGAAMAPTL3MBTL1EEF2K | |
| SCHEMBL20446262 | 0.81 | RIPK1 (0.43) | EEF2KGSK3BEPHX2RIPK1GPR88 | |
| SCHEMBL20446264 | 0.81 | RIPK1 (0.43) | EEF2KGSK3BEPHX2RIPK1GPR88 | |
| SCHEMBL321238 | 0.81 | KDM4E (0.47) | KDM4EGAAMAPTL3MBTL1EEF2K | |
| SCHEMBL25295634 | 0.79 | LMNA (0.51) | EPHX2RIPK1GPR88MEN1KMT2A | |
| SCHEMBL21839155 | 0.79 | RIPK1 (0.45) | GSK3BEPHX2RIPK1GPR88 | |
| SCHEMBL15912993 | 0.79 | MAPT (0.46) | KDM4EGAAMAPTL3MBTL1EEF2K | |
| SCHEMBL25295633 | 0.79 | LMNA (0.51) | EPHX2RIPK1GPR88MEN1KMT2A | |
| SCHEMBL25353842 | 0.79 | RIPK1 (0.45) | GSK3BEPHX2RIPK1GPR88 | |
| SCHEMBL15229201 | 0.79 | RIPK1 (0.45) | GSK3BEPHX2RIPK1GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220425-A1 | BCL-XL/BCL-2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |