SCHEMBL26650673

SCHEMBL26650673

Nc1cc(Br)c2nccn2c1

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.49
NUDT1 P36639 1/20 0.45
HTR2C P28335 1/20 0.36
DYRK1A Q13627 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
AURKA O14965 1/20 0.32
ADORA2A P29274 2/20 0.32
AXL P30530 1/20 0.32
PIK3R1 P27986 1/20 0.31
PIK3CA P42336 1/20 0.31
CD63 P08962 2/20 0.31
SYK P43405 2/20 0.31
TNKS O95271 1/20 0.30
KEAP1 Q14145 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30871010 0.82 NUDT1 (0.50) L3MBTL1NUDT1HTR2CDYRK1AAURKA
SCHEMBL1576816 0.80 L3MBTL1 (0.67) L3MBTL1NUDT1HTR2CAXLTNKS
Hydrochloric Acid SCHEMBL1369700 0.78 L3MBTL1 (0.65) L3MBTL1NUDT1HTR2CAXLTNKS
SCHEMBL15747098 0.77 L3MBTL1 (0.49) L3MBTL1NUDT1HTR2CAXLTNKS
SCHEMBL1983144 0.77 L3MBTL1 (0.49) L3MBTL1NUDT1HTR2CAURKAAXL
SCHEMBL2266179 0.77 L3MBTL1 (0.58) L3MBTL1NUDT1HTR2CAXLTNKS
SCHEMBL19456724 0.77 L3MBTL1 (0.49) L3MBTL1NUDT1HTR2CADORA2AAXL
SCHEMBL24077214 0.77 L3MBTL1 (0.62) L3MBTL1NUDT1HTR2CDYRK1AAURKA
SCHEMBL25310988 0.77 NUDT1 (0.45) L3MBTL1NUDT1HTR2CDYRK1AMAPT
SCHEMBL25310547 0.77 NUDT1 (0.45) L3MBTL1NUDT1HTR2CDYRK1AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4695246-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES Syngenta Crop Protection AG (CH) 2026-02-18 EP disclosed
WO-2025064565-A1 TRICYCLIC BENZOTHIAZOLES FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2025-03-27 WO disclosed
EP-4524135-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF Shanghai Apeiron Therapeutics Company Limited (CN) 2025-03-19 EP disclosed
CN-119212988-A Kinesin KIF18A inhibitor and application thereof 上海湃隆生物科技有限公司 2024-12-27 CN disclosed
WO-2024213653-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-10-17 WO disclosed
WO-2024083208-A1 KIF18A PROTEIN INHIBITOR 杭州邦顺制药有限公司 2024-04-25 WO disclosed
CN-117917405-A KIF18A protein inhibitors 杭州邦顺制药有限公司 2024-04-23 CN disclosed
WO-2023217230-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF 上海湃隆生物科技有限公司 2023-11-16 WO disclosed