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SCHEMBL2665047

SCHEMBL2665047

O=C(/C=C(\C(=O)c1ccc(C(=O)NC[C@@H](O)C(=O)O)cc1)c1ccc(OC(F)(F)F)cc1)c1cccc(SC(F)(F)F)c1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GCGR P47871 6/20 0.45
▸ GIPR P48546 3/20 0.43
▸ TRPV1 Q8NER1 10/20 0.40
▸ KCNK2 O95069 1/20 0.39
▸ KCNK10 P57789 1/20 0.39
▸ MAPK14 Q16539 1/20 0.38
▸ EPHX2 P34913 1/20 0.37
▸ PPARG P37231 1/20 0.37
▸ PPARA Q07869 1/20 0.37
▸ HTR2C P28335 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2665074 0.86 GCGR (0.46) GCGRGIPRTRPV1KCNK2KCNK10
SCHEMBL2665050 0.84 GCGR (0.55) GCGRGIPRPPARGPPARA
SCHEMBL2665131 0.84 GCGR (0.46) GCGRGIPRTRPV1MAPK14EPHX2
SCHEMBL2664962 0.84 GCGR (0.40) GCGRGIPRMAPK14
SCHEMBL2664963 0.84 GCGR (0.41) GCGRGIPRMAPK14
SCHEMBL2665119 0.83 GCGR (0.51) GCGRGIPRTRPV1MAPK14EPHX2
SCHEMBL2647008 0.83 GCGR (0.51) GCGRGIPRTRPV1MAPK14EPHX2
SCHEMBL2647002 0.83 GCGR (0.51) GCGRGIPRTRPV1MAPK14EPHX2
SCHEMBL9071437 0.83 GCGR (0.58) GCGRGIPRTRPV1EPHX2PPARG
SCHEMBL2665219 0.82 GCGR (0.58) GCGRGIPRTRPV1EPHX2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003048109-A1 NOVEL GLUCAGON ANTAGONISTS NOVO NORDISK A/S (DK) 2003-06-12 — — WO disclosed