Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 14/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2665316 | 0.89 | GCK (0.45) | KCNH2GCK | |
| SCHEMBL2665311 | 0.89 | GCK (0.46) | KCNH2GCK | |
| SCHEMBL2665271 | 0.88 | KCNH2 (0.46) | KCNH2GCK | |
| SCHEMBL2665285 | 0.87 | GCK (0.47) | KCNH2GCK | |
| SCHEMBL2665312 | 0.86 | GCK (0.44) | KCNH2GCK | |
| SCHEMBL9072584 | 0.86 | KCNH2 (0.61) | KCNH2GCK | |
| SCHEMBL2665334 | 0.86 | KCNH2 (0.61) | KCNH2GCK | |
| SCHEMBL2665324 | 0.85 | KCNH2 (0.52) | KCNH2GCK | |
| SCHEMBL2665262 | 0.84 | GCK (0.48) | KCNH2GCK | |
| SCHEMBL2665275 | 0.83 | GCK (0.47) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132425-B2 | 5-substituted-six-membered heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-11-07 | — | — | US | disclosed |