Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 17/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 13/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 13/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 10/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30658001 | 1.00 | PBRM1 (0.34) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26804404 | 0.85 | PBRM1 (0.41) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26654239 | 0.81 | PBRM1 (0.42) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26654147 | 0.80 | SMARCA2 (0.45) | PBRM1SMARCA2SMARCA4 | |
| SCHEMBL26654149 | 0.79 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26653968 | 0.79 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26654141 | 0.79 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26654073 | 0.75 | PBRM1 (0.36) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL30658010 | 0.75 | — | — | |
| SCHEMBL26653880 | 0.74 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |