Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 4/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26654155 | 0.85 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1OPRM1OGFRL1 | |
| SCHEMBL30658053 | 0.85 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1OPRM1OGFRL1 | |
| SCHEMBL30657990 | 0.85 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1OPRM1OGFRL1 | |
| SCHEMBL26654143 | 0.85 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1OPRM1OGFRL1 | |
| SCHEMBL30658019 | 0.84 | AVPR1A (0.46) | OXTRAVPR1AOPRM1OGFRL1OPRD1 | |
| SCHEMBL31588964 | 0.84 | AVPR1A (0.46) | OXTRAVPR1AOPRM1OGFRL1OPRD1 | |
| SCHEMBL26653853 | 0.81 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1OPRM1OGFRL1 | |
| SCHEMBL30658035 | 0.81 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1OPRM1OGFRL1 | |
| SCHEMBL30658001 | 0.80 | PBRM1 (0.34) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL26654131 | 0.80 | PBRM1 (0.34) | SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-10-02 | — | — | US | disclosed |
| CN-120035593-A | Pyrazine derivatives and uses thereof | 福宏治疗公司 | 2025-05-23 | — | — | CN | disclosed |
| EP-4522279-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | BRCA1, VHL, SF3B5 | SMARCA2 77/4885SMARCA4 19/4885PBRM1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.