Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.53 |
| ▸ | GAA | P10253 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 12/20 | 0.51 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273716 | 1.00 | NPC1 (0.53) | NPC1GAAHPGDRAB9APKM | |
| SCHEMBL268003 | 0.91 | NPC1 (0.57) | NPC1GAARAB9APKMPOLB | |
| SCHEMBL273718 | 0.91 | NPC1 (0.57) | NPC1GAARAB9APKMPOLB | |
| SCHEMBL268992 | 0.89 | RAB9A (0.57) | NPC1GAAHPGDRAB9APKM | |
| SCHEMBL274137 | 0.89 | RAB9A (0.57) | NPC1GAAHPGDRAB9APKM | |
| SCHEMBL266482 | 0.88 | NPC1 (0.58) | NPC1GAARAB9APKMPOLB | |
| SCHEMBL273711 | 0.88 | NPC1 (0.58) | NPC1GAARAB9APKMPOLB | |
| SCHEMBL273516 | 0.88 | NPC1 (0.53) | NPC1GAARAB9APKMPOLB | |
| SCHEMBL265842 | 0.88 | NPC1 (0.53) | NPC1GAARAB9APKMPOLB | |
| SCHEMBL265301 | 0.87 | CYP2D6 (0.55) | NPC1HPGDRAB9APKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134015-B2 | Compound inhibiting in vivo phosphorous transport and medicine containing the same | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-03-13 | — | — | US | disclosed |