Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17359685 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4001656 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1L3MBTL1HIF1ANPSR1 | |
| SCHEMBL1630077 | 0.73 | HIF1A (0.48) | SMN1; SMN2ALDH1A1L3MBTL1HIF1ANPSR1 | |
| SCHEMBL11590602 | 0.73 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL13447860 | 0.72 | PDE2A (0.43) | SMN1; SMN2NISCHALDH1A1HIF1ANPSR1 | |
| SCHEMBL11590609 | 0.72 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL29901001 | 0.72 | NISCH (0.52) | SMN1; SMN2PIM1SRCGSK3ANISCH | |
| SCHEMBL13830012 | 0.72 | NISCH (0.52) | SMN1; SMN2PIM1SRCGSK3ANISCH | |
| SCHEMBL19207105 | 0.71 | CSNK2A1 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL12763610 | 0.71 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1L3MBTL1KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002074773-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |