Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 2/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606405 | 1.00 | EPHX1 (0.41) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL2606335 | 0.98 | EPHX1 (0.38) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL2606404 | 0.87 | ALOX5 (0.45) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL19458771 | 0.87 | ALOX5 (0.45) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL11234464 | 0.87 | ALOX5 (0.45) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL2754 | 0.87 | ALOX5 (0.45) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| Hydrochloric Acid SCHEMBL13518199 | 0.85 | ALOX5 (0.43) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| Urea SCHEMBL2807369 | 0.85 | ALOX5 (0.43) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL2170733 | 0.85 | ALOX5 (0.43) | EPHX1HSD11B1ALOX5PHGDHS1PR3 | |
| SCHEMBL9547539 | 0.82 | ALOX5 (0.44) | EPHX1HSD11B1ALOX5PHGDHS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066145-A1 | HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-07-21 | — | — | WO | disclosed |