Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 3/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2664563 | 0.83 | GCK (0.46) | GCKRARARARBRARGCSNK2A2 | |
| SCHEMBL13703963 | 0.75 | GCK (0.39) | GCKRARARARBRARGCSNK2A2 | |
| SCHEMBL13870309 | 0.74 | GCK (0.58) | GCKRARARARBRARG | |
| SCHEMBL2664562 | 0.72 | GCK (0.46) | GCKRARARARBRARGCSNK2A2 | |
| SCHEMBL19774516 | 0.71 | GCK (0.66) | GCK | |
| SCHEMBL2666387 | 0.71 | PARP10 (0.49) | GCKALDH1A1TSHR | |
| SCHEMBL2664771 | 0.70 | GCK (0.43) | GCKALDH1A1TSHRRARARARB | |
| SCHEMBL1261486 | 0.70 | GCK (0.47) | GCKRARARARBRARGCSNK2A2 | |
| SCHEMBL3605637 | 0.70 | GCK (0.68) | GCK | |
| SCHEMBL2664777 | 0.70 | GCK (0.55) | GCKRARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003015774-A1 | COMPOUNDS EFFECTING GLUCOKINASE | ASTRAZENECA AB (SE) | 2003-02-27 | — | — | WO | disclosed |