Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betaxolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 2/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.88 |
| ▸ | GAA | P10253 | 1/20 | 0.88 |
| ▸ | BLM | P54132 | 1/20 | 0.88 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.88 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.88 |
| ▸ | NPY1R | P25929 | 1/20 | 0.62 |
| ▸ | NPY2R | P49146 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betaxolol SCHEMBL26664793 | 0.96 | ADRB1 (0.90) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL26664797 | 0.95 | ADRB1 (0.88) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL4997902 | 0.95 | ADRB1 (1.00) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL23531 | 0.95 | ADRB1 (1.00) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Levobetaxolol SCHEMBL23532 | 0.95 | ADRB1 (1.00) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL23530 | 0.95 | ADRB1 (1.00) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL6512495 | 0.95 | ADRB1 (1.00) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL26664804 | 0.94 | ADRB1 (0.86) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL26664771 | 0.94 | ADRB1 (0.86) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| Betaxolol SCHEMBL26664776 | 0.94 | ADRB1 (0.86) | ADRB1LMNACYP2D6MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023221852-A1 | COMPOUND PHARMACEUTICAL COMPOSITION FOR TREATING GLAUCOMA AND USE THEREOF | 沈阳药科大学 | 2023-11-23 | — | — | WO | claimed |
| CN-114796219-A | Compound pharmaceutical composition for treating glaucoma and application thereof | 沈阳药科大学 | 2022-07-29 | — | — | CN | claimed |
| WO-2023221852-A1 | COMPOUND PHARMACEUTICAL COMPOSITION FOR TREATING GLAUCOMA AND USE THEREOF | 沈阳药科大学 | 2023-11-23 | — | — | WO | disclosed |
| CN-114796219-A | Compound pharmaceutical composition for treating glaucoma and application thereof | 沈阳药科大学 | 2022-07-29 | — | — | CN | disclosed |