Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423133 | 0.84 | KIF11 (0.47) | KIF11KDM4ERAD52ATMMMP12 | |
| SCHEMBL19265080 | 0.77 | GSTP1 (0.32) | KIF11 | |
| SCHEMBL2666085 | 0.75 | TSHR (0.37) | KDM4ERAD52ATMMMP12 | |
| SCHEMBL19454304 | 0.72 | CYP1A2 (0.35) | — | |
| SCHEMBL20714875 | 0.72 | MMP12 (0.36) | KDM4ERAD52ATMMMP12 | |
| SCHEMBL14449328 | 0.71 | KDM4E (0.33) | KDM4ERAD52ATMMMP12 | |
| SCHEMBL14449361 | 0.69 | PDK2 (0.33) | — | |
| SCHEMBL10104551 | 0.69 | KIF11 (0.38) | KIF11 | |
| SCHEMBL14449359 | 0.68 | KDM4E (0.33) | KDM4E | |
| SCHEMBL14985671 | 0.66 | PDK2 (0.40) | KDM4ERAD52ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006104826-A2 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2006-10-05 | — | — | WO | disclosed |