Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.42 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26669327 | 0.80 | TEAD1 (0.42) | PTGS2STK17BCSF1RIKBKEAAK1 | |
| SCHEMBL26669267 | 0.80 | FLT1 (0.39) | PTGS2STK17BCSF1RIKBKEAAK1 | |
| SCHEMBL26669262 | 0.80 | PTGS2 (0.47) | PTGS2CSF1RAPPEPHX2CA1 | |
| SCHEMBL26669315 | 0.77 | PDE2A (0.37) | PTGS2STK17BCSF1RIKBKEAAK1 | |
| SCHEMBL26669273 | 0.75 | RPS6KB1 (0.39) | PTGS2STK17BCSF1RIKBKEAAK1 | |
| SCHEMBL29704121 | 0.73 | CA1 (0.53) | PTGS2CA1CA2CRHR1CA12 | |
| SCHEMBL24496030 | 0.71 | MAPT (0.44) | PTGS2EPHX2EGFRPDE2AHDAC3 | |
| SCHEMBL29704153 | 0.70 | CA1 (0.52) | PTGS2CA1CA2CRHR1CA12 | |
| SCHEMBL1267906 | 0.70 | CRHR1 (0.44) | PTGS2APPEPHX2CRHR1HDAC3 | |
| SCHEMBL26669331 | 0.69 | CA1 (0.42) | EPHX2CA1CA2EGFRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |