Sugi Predict

Sugi Predict / Compounds / SCHEMBL26670547

SCHEMBL26670547

SCHEMBL26670547

Cc1nn2ccc(OCc3ccccc3F)cc2c1C(=O)NC(C)(CO)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GUCY1B2 O75343 6/20 0.42
▸ GUCY1A2 P33402 6/20 0.42
▸ GUCY1A1 Q02108 6/20 0.42
▸ GUCY1B1 Q02153 6/20 0.42
▸ PTPN1 P18031 2/20 0.39
▸ POLB P06746 2/20 0.37
▸ GCK P35557 2/20 0.37
▸ RARA P10276 1/20 0.37
▸ RARB P10826 1/20 0.37
▸ RARG P13631 1/20 0.37
▸ MAOB P27338 2/20 0.36
▸ PARP15 Q460N3 1/20 0.36
▸ PARP10 Q53GL7 1/20 0.36
▸ SLC16A3 O15427 1/20 0.36
▸ SLC16A1 P53985 1/20 0.36
▸ MCTS1 Q9ULC4 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26670552 0.92 GUCY1B2 (0.40) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL26670493 0.92 GUCY1B2 (0.40) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL26670513 0.92 GUCY1B2 (0.40) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL30668934 0.91 GUCY1B2 (0.39) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL26829336 0.91 GUCY1B2 (0.39) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL30668953 0.90 GUCY1B2 (0.42) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL26829246 0.90 GUCY1B2 (0.42) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL30668948 0.86 PARP10 (0.41) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL26829249 0.86 PARP10 (0.41) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1
SCHEMBL30668940 0.86 GUCY1B2 (0.39) GUCY1B2GUCY1A2GUCY1A1GUCY1B1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376468-A1 PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2025-12-11 — — US disclosed
CN-119998280-A Pyrazolo [1,5-a ] pyridine derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-05-13 — — CN disclosed
EP-4499636-A2 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-02-05 — — EP disclosed
WO-2023230542-A2 PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 — — WO disclosed
WO-2023230542-A2 PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250376468-A1 PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS TRPV3, TRPM5, TRPM4 GUCY1B2 3171/4885GUCY1A2 3012/4885GUCY1A1 2710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.