Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737377 | 0.79 | SMN1; SMN2 (0.49) | MYCWDR5CDK2SLC22A12NOS1 | |
| SCHEMBL738352 | 0.76 | CDK2 (0.48) | MYCWDR5CDK2CSNK2A1NOS1 | |
| SCHEMBL2606389 | 0.69 | MYC (0.44) | MYCWDR5CDK2CSNK2A1SMN1; SMN2 | |
| SCHEMBL15824227 | 0.68 | MYC (0.43) | MYCWDR5CDK2CSNK2A1NOS1 | |
| SCHEMBL702948 | 0.68 | — | — | |
| SCHEMBL9098198 | 0.67 | MYC (0.59) | MYCWDR5CDK2CSNK2A1NOS1 | |
| SCHEMBL9072653 | 0.67 | APEX1 (0.47) | MYCWDR5CDK2CSNK2A1SMN1; SMN2 | |
| SCHEMBL19018619 | 0.65 | HSP90AB1 (0.44) | MYCWDR5CDK2SMN1; SMN2 | |
| SCHEMBL2656865 | 0.65 | CDK2 (0.49) | MYCWDR5CDK2SMN1; SMN2 | |
| SCHEMBL23224219 | 0.65 | SMN1; SMN2 (0.50) | CDK2CSNK2A1NOS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377856-A1 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2011-10-19 | — | — | EP | disclosed |
| WO-2007006760-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |