Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.48 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 13/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 6/20 | 0.36 |
| ▸ | CCND1 | P24385 | 6/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.36 |
| ▸ | CDK1 | P06493 | 4/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735616 | 0.82 | SMN1; SMN2 (0.47) | CDK2MYCWDR5CCNE2CCNE1 | |
| SCHEMBL2667255 | 0.76 | PPARA (0.49) | CDK2MYCWDR5CSNK2A1SMN1; SMN2 | |
| SCHEMBL2606389 | 0.76 | MYC (0.44) | CDK2MYCWDR5CSNK2A1CCNE2 | |
| SCHEMBL9072653 | 0.73 | APEX1 (0.47) | CDK2MYCWDR5CSNK2A1CCNE2 | |
| SCHEMBL16086926 | 0.71 | CDK2 (0.49) | CDK2MYCWDR5CSNK2A1CCNE2 | |
| SCHEMBL5875895 | 0.71 | — | — | |
| SCHEMBL2656865 | 0.71 | CDK2 (0.49) | CDK2MYCWDR5CCNE2CCNE1 | |
| SCHEMBL19018619 | 0.71 | HSP90AB1 (0.44) | CDK2MYCWDR5CCNE2CCNE1 | |
| SCHEMBL2667029 | 0.70 | CDK2 (0.45) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL688576 | 0.69 | CCNB2 (0.64) | CDK2CCNE2CCNE1SMN1; SMN2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013057944-A1 | NOVEL SPIROINDOLINE COMPOUND, AND MEDICINAL AGENT COMPRISING SAME | 興和株式会社 (JP) | 2013-04-25 | — | — | WO | disclosed |
| US-8138185-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| EP-2377856-A1 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2011-10-19 | — | — | EP | disclosed |
| US-20100009989-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| EP-2118083-A1 | UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008084043-A1 | UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008084043-A1 | UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009989-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | CDK2 381/4885MYC 1966/4885WDR5 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.