Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611826 | 0.83 | HSD11B1 (0.58) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL14277202 | 0.83 | HSD11B1 (0.44) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL5095918 | 0.82 | HSD11B1 (0.51) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL14277204 | 0.81 | MAPK1 (0.49) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL5098164 | 0.81 | HSD11B1 (0.43) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL5098113 | 0.80 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL5092143 | 0.79 | HSD11B1 (0.62) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL5098587 | 0.78 | MAPK1 (0.47) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL14277211 | 0.78 | HSD11B1 (0.52) | MEN1KMT2AALDH1A1MAPK1HSD11B1 | |
| SCHEMBL5092083 | 0.78 | MEN1 (0.48) | MEN1KMT2AALDH1A1MAPK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| WO-2004110375-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | disclosed |