SCHEMBL2667583

SCHEMBL2667583

COC[C@@H](C)Oc1cc(C(=O)Nc2cc[nH]n2)cc(Oc2ccc(F)cc2)n1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.49
RARG P13631 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9071023 0.93 GCK (0.54) GCKRARG
SCHEMBL2667830 0.90 GCK (0.57) GCKRARG
SCHEMBL2668005 0.89 GCK (0.45) GCKRARG
SCHEMBL9071059 0.89 GCK (0.51) GCKRARG
SCHEMBL9070995 0.88 GCK (0.40) GCK
SCHEMBL2667808 0.88 GCK (0.47) GCKRARG
SCHEMBL2667571 0.86 GCK (0.47) GCK
SCHEMBL9071056 0.85 GCK (0.59) GCK
SCHEMBL2667576 0.84 GCK (0.71) GCKRARG
SCHEMBL2667589 0.84 GCK (0.67) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009083553-A1 AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS RHEOSCIENCE A/S (DK) 2009-07-09 WO disclosed