SCHEMBL26675950

SCHEMBL26675950

O=C(N1CCc2oc3ccc(O)cc3c2CC1)C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2C19 P33261 1/20 0.54
ESR1 P03372 9/20 0.53
ESR2 Q92731 9/20 0.53
PRKD1 Q15139 3/20 0.40
ALDH1A1 P00352 3/20 0.39
LMNA P02545 2/20 0.39
TP53 P04637 2/20 0.39
HTT P42858 1/20 0.39
CDK5 Q00535 1/20 0.39
CDK5R1 Q15078 1/20 0.39
PRKD2 Q9BZL6 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
POLB P06746 2/20 0.37
KDM4E B2RXH2 1/20 0.37
HSD17B10 Q99714 1/20 0.37
GAA P10253 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29736346 1.00 CYP3A4 (0.54) CYP3A4CYP1A2CYP2C19ESR1ESR2
SCHEMBL29736223 0.87 ESR1 (0.41) CYP3A4CYP1A2CYP2C19ESR1ESR2
SCHEMBL26675898 0.87 ESR1 (0.41) CYP3A4CYP1A2CYP2C19ESR1ESR2
SCHEMBL29736208 0.86 RAB9A (0.44) CYP3A4CYP1A2CYP2C19ESR1ESR2
SCHEMBL26675924 0.86 RAB9A (0.44) CYP3A4CYP1A2CYP2C19ESR1ESR2
SCHEMBL29736024 0.83 MTHFD2 (0.44) ESR1ESR2ALDH1A1LMNATP53
SCHEMBL26675952 0.83 MTHFD2 (0.44) ESR1ESR2ALDH1A1LMNATP53
SCHEMBL373697 0.72 ESR2 (0.83) ESR1ESR2
SCHEMBL29736328 0.72 ESR1 (0.41) CYP3A4CYP1A2CYP2C19ESR1ESR2
SCHEMBL26675940 0.72 ESR1 (0.41) CYP3A4CYP1A2CYP2C19ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4288048-A1 OXA-IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS The Trustees Of Columbia University In The City Of New York (US) 2023-12-13 EP disclosed
US-20230382919-A1 OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-11-30 US disclosed
US-20230382919-A1 OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-11-30 US disclosed
US-20230382919-A1 OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230382919-A1 OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS GRIA4, GRIA3, GRIN3A CYP3A4 238/4885CYP1A2 400/4885CYP2C19 629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.