Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CPT1A | P50416 | 2/20 | 0.43 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667678 | 0.92 | MAPK1 (0.59) | GCKGAAMAPTMAPK1KCNH2 | |
| SCHEMBL2667802 | 0.91 | GCK (0.50) | GCKMAPK1KCNH2GRM5CPT1A | |
| SCHEMBL2667555 | 0.91 | GCK (0.53) | GCKGAAMAPTMAPK1TDP1 | |
| SCHEMBL9071021 | 0.88 | GCK (0.51) | GCKMAPTMAPK1KCNH2GRM5 | |
| SCHEMBL2667538 | 0.87 | GCK (0.50) | GCKKCNH2GRM5CPT1ACPT1B | |
| SCHEMBL2667580 | 0.87 | GCK (0.50) | GCKKCNH2GRM5CPT1ACPT1B | |
| SCHEMBL2667999 | 0.85 | MAPT (0.49) | GCKGAAMAPTMAPK1KCNH2 | |
| SCHEMBL2668009 | 0.85 | GRM5 (0.48) | GCKGAAMAPTMAPK1KCNH2 | |
| SCHEMBL2667961 | 0.85 | ALDH1A1 (0.49) | GCKKCNH2GRM5SCDPDE5A | |
| SCHEMBL2667683 | 0.85 | GCK (0.63) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |