SCHEMBL2667792

SCHEMBL2667792

C[C@H](CO)Oc1cc(C(=O)Nc2cc[nH]n2)cc(Oc2ccc(S(C)(=O)=O)cc2)n1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.51
KCNH2 Q12809 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2667675 0.91 GCK (0.52) GCKKCNH2
SCHEMBL3601775 0.87 GCK (0.66) GCKKCNH2
SCHEMBL3241694 0.87 GCK (0.66) GCKKCNH2
SCHEMBL2667822 0.84 GCK (0.67) GCK
SCHEMBL9071040 0.83 GCK (0.48) GCKKCNH2
SCHEMBL2667571 0.82 GCK (0.47) GCKKCNH2
SCHEMBL2667377 0.81 ALDH1A1 (0.44) GCK
SCHEMBL2667821 0.81 GCK (0.54) GCKKCNH2
SCHEMBL9071023 0.80 GCK (0.54) GCKKCNH2
SCHEMBL13209620 0.80 GCK (0.57) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009083553-A1 AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS RHEOSCIENCE A/S (DK) 2009-07-09 WO disclosed