Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667625 | 1.00 | HSD11B1 (0.78) | HSD11B1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16868571 | 0.80 | HSD11B1 (0.83) | HSD11B1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4528572 | 0.76 | HSD11B1 (0.63) | HSD11B1 | |
| SCHEMBL13902471 | 0.75 | HSD11B1 (0.60) | HSD11B1 | |
| SCHEMBL4102633 | 0.75 | HSD11B1 (0.66) | HSD11B1 | |
| SCHEMBL4102630 | 0.75 | HSD11B1 (0.66) | HSD11B1 | |
| SCHEMBL13902468 | 0.75 | HSD11B1 (0.66) | HSD11B1 | |
| SCHEMBL4360892 | 0.74 | HSD11B1 (0.60) | HSD11B1 | |
| SCHEMBL2667471 | 0.74 | HSD11B1 (0.79) | HSD11B1 | |
| SCHEMBL5638283 | 0.71 | HSD11B1 (0.56) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004110375-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | disclosed |