Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11002637 | 0.90 | CYP1A2 (0.47) | LMNAALDH1A1CYP1A2 | |
| SCHEMBL9406976 | 0.87 | LMNA (0.37) | LMNAALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL9406978 | 0.87 | LMNA (0.37) | LMNAALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL11743536 | 0.84 | METAP1 (0.33) | — | |
| SCHEMBL9406967 | 0.83 | CYP1A2 (0.48) | LMNAALDH1A1MAPTCYP1A2MAPK1 | |
| SCHEMBL9406960 | 0.83 | CYP1A2 (0.48) | LMNAALDH1A1MAPTCYP1A2MAPK1 | |
| SCHEMBL4761965 | 0.81 | LMNA (0.42) | LMNAALDH1A1MAPTCYP1A2MAPK1 | |
| SCHEMBL10999008 | 0.80 | ALDH1A1 (0.50) | LMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL10997418 | 0.79 | CYP1A2 (0.53) | LMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL111175 | 0.79 | CYP1A2 (0.53) | LMNAALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229356-B1 | 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS | NOVARTIS AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| EP-2235017-B1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2011-09-14 | — | — | EP | disclosed |
| WO-2006016174-A1 | FLUORINATION PROCESS OF PROTECTED AMINOTHIAZOLE | PROSIDION LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |