Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 5/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2668284 | 0.85 | HPGD (0.54) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL712484 | 0.83 | PRMT5 (0.52) | NPC1ALDH1A1TP53HPGDRAB9A | |
| SCHEMBL10206825 | 0.74 | PRMT5 (0.51) | NPC1ALDH1A1TP53HPGDRAB9A | |
| SCHEMBL10266345 | 0.74 | AURKA (0.58) | NPC1ALDH1A1TP53HPGDRAB9A | |
| SCHEMBL2668288 | 0.71 | PDE5A (0.53) | NPC1ALDH1A1TP53HPGDRAB9A | |
| SCHEMBL7393911 | 0.71 | AURKA (0.66) | PRMT5PDE5AAURKAFAAHMETAP2 | |
| SCHEMBL10744129 | 0.70 | AURKA (0.70) | ALDH1A1HPGDHSD17B10PRMT5PDE5A | |
| SCHEMBL7434682 | 0.69 | AURKA (0.68) | PRMT5PDE5AAURKAMETAP2METAP1 | |
| SCHEMBL712532 | 0.69 | PRMT5 (0.43) | NPC1ALDH1A1TP53HPGDRAB9A | |
| SCHEMBL10206833 | 0.68 | HPGD (0.52) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007028135-A2 | IMIDAZOPYRIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |