Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MRE11 | P49959 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656187 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2660279 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2658175 | 0.74 | POLB (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL10200000 | 0.71 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL2657189 | 0.70 | MAPT (0.44) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2656339 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2656819 | 0.69 | PPARA (0.43) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2657487 | 0.69 | GCK (0.67) | SMN1; SMN2ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2657687 | 0.67 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL2658354 | 0.67 | MAPT (0.46) | SMN1; SMN2ALDH1A1RAB9ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104994-A2 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2008-09-04 | — | — | WO | disclosed |