Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619123 | 0.83 | TP53 (0.46) | KDM4ETDP1TP53ALDH1A1MAPT | |
| SCHEMBL1619405 | 0.81 | KDM4E (0.49) | KDM4ETDP1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1619176 | 0.80 | RAB9A (0.39) | KDM4ETDP1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL1617826 | 0.80 | HPGD (0.55) | KDM4ETDP1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1619404 | 0.80 | ALDH1A1 (0.49) | TDP1TP53ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1619269 | 0.79 | KMT2A (0.49) | KDM4ETDP1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL1619379 | 0.79 | KDM4E (0.41) | KDM4ETDP1TP53ALDH1A1ITGB3 | |
| SCHEMBL1618951 | 0.79 | KDM4E (0.39) | KDM4ETDP1TP53ALDH1A1POLB | |
| SCHEMBL1619203 | 0.78 | CHRM1 (0.43) | KDM4ETDP1ALDH1A1ITGB3ITGAV | |
| SCHEMBL1619459 | 0.77 | SCN9A (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053662-A1 | DIHYDROISOINDOLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |