Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 13/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 12/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 12/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31570184 | 1.00 | PBRM1 (0.41) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL26685046 | 0.83 | PBRM1 (0.41) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL31570150 | 0.83 | PBRM1 (0.41) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL26685332 | 0.82 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL31570145 | 0.82 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL26683624 | 0.80 | PBRM1 (0.41) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL26684798 | 0.80 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL26888673 | 0.76 | QDPR (0.47) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL31570175 | 0.73 | SMARCA2 (0.47) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL26685015 | 0.73 | SMARCA2 (0.47) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522278-A1 | BENZOYPARAZINE PYRAZINES ANE THEIR USES | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220129-A1 | BENZOYPARAZINE PYRAZINES ANE THEIR USES | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220129-A1 | BENZOYPARAZINE PYRAZINES ANE THEIR USES | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |