Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27534348 | 0.81 | — | — | |
| SCHEMBL28650157 | 0.78 | BCHE (0.37) | KDM4E | |
| SCHEMBL8211209 | 0.72 | HPGD (0.36) | HPGDTSHRP2RX4KDM4EALDH1A1 | |
| SCHEMBL27620589 | 0.71 | — | — | |
| SCHEMBL3783557 | 0.70 | P2RX4 (0.33) | CYP2C9TSHRP2RX4KDM4EALDH1A1 | |
| Bicarbonate SCHEMBL4853459 | 0.68 | CYP2B6 (0.41) | KDM4EMEN1KMT2A | |
| Bicarbonate SCHEMBL2467502 | 0.68 | CYP2B6 (0.41) | KDM4EMEN1KMT2A | |
| SCHEMBL29376182 | 0.67 | P2RX4 (0.44) | TSHRP2RX4MEN1KMT2ALMNA | |
| SCHEMBL3375661 | 0.67 | P2RX4 (0.44) | TSHRP2RX4MEN1KMT2ALMNA | |
| Bicarbonate SCHEMBL8638184 | 0.67 | CYP2B6 (0.40) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3935060-B1 | FUSED TRICYCLIC COMPOUNDS USEFUL AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2023-11-15 | — | — | EP | disclosed |