Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 9/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107547 | 0.85 | GCK (0.52) | ALDH1A1MAPK1GCKLMNAMEN1 | |
| SCHEMBL2669005 | 0.85 | GCK (0.47) | GCKFFAR1KCNH2 | |
| SCHEMBL1107744 | 0.78 | GCK (0.56) | GCKMEN1KMT2AKCNH2 | |
| SCHEMBL21704383 | 0.76 | ALDH1A1 (0.70) | ALDH1A1MAPK1L3MBTL1LMNAMEN1 | |
| SCHEMBL12594271 | 0.76 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL1107721 | 0.75 | GCK (0.55) | GCKMAPTKCNH2 | |
| SCHEMBL2668841 | 0.75 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL2656511 | 0.75 | HPGD (0.52) | ALDH1A1GCKFFAR1LMNAMEN1 | |
| SCHEMBL2668144 | 0.74 | GCK (0.46) | GCKMEN1NPC1MAPTRAB9A | |
| SCHEMBL18179855 | 0.74 | ALDH1A1 (0.69) | ALDH1A1MAPK1L3MBTL1FFAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005964-A2 | PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |