SCHEMBL2669005 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	GCK	P35557	12/20	0.47

▸	KCNH2	Q12809	2/20	0.43

▸	FFAR1	O14842	2/20	0.42

▸	MMP2	P08253	1/20	0.40

▸	MMP9	P14780	1/20	0.40

▸	MMP8	P22894	1/20	0.40

▸	MMP12	P39900	1/20	0.40

▸	MMP13	P45452	1/20	0.40

▸	MMP14	P50281	1/20	0.40

▸	MMP16	P51512	1/20	0.40

▸	PTGDR2	Q9Y5Y4	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1107744	0.85	GCK (0.56)	GCKKCNH2
SCHEMBL2669019	0.85	ALDH1A1 (0.43)	GCKKCNH2FFAR1
SCHEMBL12594271	0.83	GCK (0.53)	GCKKCNH2
SCHEMBL1107501	0.83	GCK (0.58)	GCKKCNH2
SCHEMBL5122670	0.83	MMP2 (0.51)	FFAR1MMP2MMP9MMP8MMP12
SCHEMBL2668841	0.82	GCK (0.53)	GCKKCNH2
SCHEMBL1107721	0.82	GCK (0.55)	GCKKCNH2
SCHEMBL2668144	0.81	GCK (0.46)	GCKKCNH2
SCHEMBL5123329	0.81	ALDH1A1 (0.44)	FFAR1MMP2MMP9MMP8MMP12
SCHEMBL5132239	0.81	ALDH1A1 (0.44)	FFAR1MMP2MMP9MMP8MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008005964-A2	PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS	BRISTOL-MYERS SQUIBB COMPANY (US)	2008-01-10	—	—	WO	disclosed