Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17576060 | 0.90 | KDM4E (0.43) | LMNASMN1; SMN2RAB9AHTTPOLB | |
| SCHEMBL2642568 | 0.88 | CSNK2A1 (0.42) | RAB9APOLBNPC1KDM4EHSD17B10 | |
| SCHEMBL1107323 | 0.86 | ALDH1A1 (0.43) | LMNASMN1; SMN2HTTALDH1A1KDM1A | |
| SCHEMBL2642679 | 0.82 | HTT (0.50) | LMNAHTTKDM4EKDM1AKMT2A | |
| SCHEMBL16166767 | 0.81 | LMNA (0.39) | LMNARAB9AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL14756161 | 0.80 | BRD4 (0.49) | LMNASMN1; SMN2RAB9AHTTPOLB | |
| SCHEMBL12444946 | 0.79 | KAT2B (0.56) | LMNASMN1; SMN2RAB9AHTTPOLB | |
| SCHEMBL10193346 | 0.75 | LMNA (0.49) | LMNASMN1; SMN2RAB9AHTTPOLB | |
| SCHEMBL18562264 | 0.74 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2RAB9AHTTPOLB | |
| SCHEMBL2227996 | 0.74 | NFATC1 (0.56) | LMNAHTTKAT2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005964-A2 | PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |