SCHEMBL2669282 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	GCK	P35557	2/20	0.49

▸	SLC6A4	P31645	7/20	0.38

▸	HRH3	Q9Y5N1	7/20	0.38

▸	ALDH1A1	P00352	1/20	0.33

▸	HSD17B10	Q99714	1/20	0.33

▸	DPP4	P27487	1/20	0.33

▸	BRD4	O60885	2/20	0.32

▸	SLC6A2	P23975	1/20	0.32

▸	SLC6A3	Q01959	1/20	0.32

▸	MEN1	O00255	1/20	0.32

▸	KMT2A	Q03164	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2669284	0.87	GCK (0.52)	GCKSLC6A4HRH3
SCHEMBL9923373	0.87	GCK (0.38)	GCKSLC6A4SLC6A2SLC6A3
SCHEMBL2669283	0.86	GCK (0.66)	GCKSLC6A4HRH3SLC6A2SLC6A3
SCHEMBL2669401	0.84	GCK (0.52)	GCKHRH3
SCHEMBL642456	0.83	GCK (0.52)	GCKSLC6A4HRH3ALDH1A1HSD17B10
SCHEMBL2643863	0.83	GCK (0.51)	GCKSLC6A4HRH3ALDH1A1HSD17B10
SCHEMBL9071962	0.81	GCK (0.43)	GCKMEN1KMT2A
SCHEMBL9071954	0.81	GCK (0.48)	GCKHRH3ALDH1A1
SCHEMBL642478	0.79	GCK (0.77)	GCKSLC6A4HRH3
SCHEMBL2669385	0.78	GCK (0.67)	GCKSLC6A4HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2007122482-A1	FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES	PFIZER PRODUCTS INC. (US)	2007-11-01	—	—	WO	disclosed