Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.66 |
| ▸ | CPS1 | P31327 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669385 | 0.91 | GCK (0.67) | GCKCPS1SLC6A4HRH3GPR119 | |
| SCHEMBL2669286 | 0.91 | GCK (0.55) | GCKCPS1GPR119 | |
| SCHEMBL9071945 | 0.91 | GCK (0.55) | GCKCPS1 | |
| SCHEMBL2669341 | 0.91 | GCK (0.59) | GCKCPS1SLC6A4HRH3GPR119 | |
| SCHEMBL2669367 | 0.91 | GCK (0.55) | GCKCPS1EZH2 | |
| SCHEMBL9923383 | 0.89 | GCK (0.53) | GCKCPS1SCN9A | |
| SCHEMBL2669284 | 0.89 | GCK (0.52) | GCKCPS1SLC6A4HRH3CNR1 | |
| SCHEMBL9071966 | 0.89 | GCK (0.53) | GCKEZH2 | |
| SCHEMBL2669236 | 0.87 | GCK (0.49) | GCKEZH2 | |
| SCHEMBL2669401 | 0.87 | GCK (0.52) | GCKHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |