Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL832850 | 0.82 | EPHX1 (0.48) | ALDH1A1KMT2AMEN1TAAR1EPHX1 | |
| SCHEMBL27875738 | 0.81 | CNR2 (0.44) | ALDH1A1LMNAKMT2AMEN1TAAR1 | |
| SCHEMBL2669647 | 0.79 | TP53 (0.49) | TP53TSHRALDH1A1MAPTRAB9A | |
| SCHEMBL31547206 | 0.78 | CNR2 (0.44) | RAB9AKMT2AMEN1TAAR1NPC1 | |
| SCHEMBL4217495 | 0.78 | ESR1 (0.43) | TSHRALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL15697965 | 0.78 | CA1 (0.55) | TP53TSHRALDH1A1MAPTRAB9A | |
| SCHEMBL38662261 | 0.77 | ALDH1A1 (0.54) | TSHRALDH1A1BACE1KMT2AMEN1 | |
| SCHEMBL6892285 | 0.76 | MAPT (0.48) | TP53TSHRALDH1A1MAPTRAB9A | |
| SCHEMBL11396984 | 0.76 | ESR1 (0.48) | TP53TSHRALDH1A1MAPTRAB9A | |
| SCHEMBL14141447 | 0.75 | TSHR (0.46) | TP53TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008098244-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | METABASIS THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |