Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | USP9X | Q93008 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.31 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.31 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.31 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266989 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL266990 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13574545 | 0.94 | NR3C1 (0.34) | OGATRPV1KCNK3P2RX7 | |
| Hydrochloric Acid SCHEMBL265960 | 0.85 | USP9X (0.34) | EP300OGASCN5ASCN9AUSP9X | |
| Hydrochloric Acid SCHEMBL265961 | 0.85 | USP9X (0.34) | EP300OGASCN5ASCN9AUSP9X | |
| Hydrochloric Acid SCHEMBL265962 | 0.85 | USP9X (0.34) | EP300OGASCN5ASCN9AUSP9X | |
| SCHEMBL271721 | 0.80 | NR3C1 (0.36) | OGATRPV1OPRM1KCNK3 | |
| SCHEMBL271525 | 0.79 | OGA (0.33) | OGATRPV1KCNK3P2RX7 | |
| SCHEMBL265895 | 0.76 | OGA (0.34) | OGASCN5ASCN9AUSP9XTRPV1 | |
| SCHEMBL265893 | 0.76 | OGA (0.34) | OGASCN5ASCN9AUSP9XTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133909-B2 | Heteroaromatic monoamides as orexinin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2297102-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009153180-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-23 | — | — | WO | disclosed |
| US-20090312314-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312314-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPSR1 | KDM4E 3175/4885ALDH1A1 1706/4885CYP1A2 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.