Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560135 | 0.82 | TNKS (0.53) | CYP2A6IMPDH2PIM1PIM3TRPA1 | |
| SCHEMBL26700816 | 0.80 | TNKS2 (0.53) | CYP2A6IMPDH2PIM1PIM3TRPA1 | |
| SCHEMBL2535062 | 0.77 | CYP2A6 (0.61) | CYP2A6IMPDH2PIM1PIM3ALDH1A1 | |
| SCHEMBL28066001 | 0.77 | BACE1 (0.52) | TRPA1ALDH1A1TRPM8ARBACE1 | |
| SCHEMBL29644219 | 0.74 | CYP2A6 (0.58) | CYP2A6IMPDH2PIM1PIM3ALDH1A1 | |
| SCHEMBL2533000 | 0.74 | CYP2A6 (0.58) | CYP2A6IMPDH2PIM1PIM3ALDH1A1 | |
| SCHEMBL7844961 | 0.73 | CYP2A6 (0.57) | CYP2A6IMPDH2PIM1PIM3ALDH1A1 | |
| SCHEMBL15331451 | 0.72 | CYP2A6 (0.53) | CYP2A6IMPDH2PIM1PIM3ALDH1A1 | |
| SCHEMBL15330461 | 0.71 | CYP2A6 (0.53) | CYP2A6IMPDH2PIM1PIM3TRPA1 | |
| SCHEMBL12907453 | 0.71 | TRPA1 (0.50) | PIM1PIM3TRPA1ALDH1A1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339886-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339886-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | NR1H2, NR1H3, NR1D1 | CYP2A6 1550/4885IMPDH2 4354/4885PIM1 4528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.