Sugi Predict

Sugi Predict / Compounds / SCHEMBL2670481

SCHEMBL2670481

SCHEMBL2670481

COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)on5)cc4F)c3s2)nc1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 10/20 0.57
▸ KDR P35968 10/20 0.57
▸ FLT3 P36888 5/20 0.57
▸ AXL P30530 2/20 0.57
▸ NTRK1 P04629 1/20 0.57
▸ KIT P10721 1/20 0.57
▸ NTRK2 Q16620 1/20 0.57
▸ MST1R Q04912 11/20 0.55
▸ PLK4 O00444 1/20 0.54
▸ MAP4K4 O95819 1/20 0.54
▸ ABL1 P00519 1/20 0.54
▸ LCK P06239 1/20 0.54
▸ FYN P06241 1/20 0.54
▸ LYN P07948 1/20 0.54
▸ HCK P08631 1/20 0.54
▸ PDGFRB P09619 1/20 0.54
▸ BCR P11274 1/20 0.54
▸ SRC P12931 1/20 0.54
▸ ABL2 P42684 1/20 0.54
▸ FRK P42685 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2670505 0.95 MET (0.57) METKDRFLT3AXLNTRK1
SCHEMBL13664099 0.92 MST1R (0.65) METKDRFLT3AXLNTRK1
SCHEMBL14817482 0.88 MET (0.58) METKDRFLT3AXLNTRK1
SCHEMBL2534639 0.88 MST1R (0.59) METKDRFLT3AXLNTRK1
SCHEMBL2670885 0.88 MET (0.73) METKDRFLT3AXLNTRK1
SCHEMBL2670807 0.88 MST1R (0.60) METKDRFLT3AXLNTRK1
SCHEMBL15698621 0.87 MET (0.57) METKDRFLT3AXLNTRK1
SCHEMBL3435606 0.87 MET (0.59) METKDRFLT3AXLNTRK1
SCHEMBL2536586 0.87 MET (0.66) METKDRFLT3AXLNTRK1
SCHEMBL15808678 0.86 MET (0.56) METKDRFLT3AXLNTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2183254-B1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC (CA) 2017-06-21 — — EP disclosed
US-8846927-B2 Inhibitors of protein tyrosine kinase activity METHYLGENE INC. (CA) 2014-09-30 — — US disclosed
US-20130165477-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2013-06-27 — — US disclosed
US-8404846-B2 Inhibitors of protein tyrosine kinase activity METHYLGENE INC. (CA) 2013-03-26 — — US disclosed
US-8389541-B2 Inhibitors of protein tyrosine kinase activity METHYLGENE INC. (CA) 2013-03-05 — — US disclosed
US-20120108628-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY Mirati Therapeutics, Inc. 2012-05-03 — — US disclosed
US-20090264440-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY Mirati Therapeutics, Inc. 2009-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130165477-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY HGF, ERBB2, MET MET 3/4885KDR 11/4885FLT3 10/4885
US-20090264440-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY HGF, ERBB2, MET MET 3/4885KDR 11/4885FLT3 10/4885
US-20120108628-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY HGF, ERBB2, MET MET 3/4885KDR 11/4885FLT3 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.